MnSOD基因单核苷酸多态性对食管癌局部放疗的影响

doi:10.3969/j.issn.1004-616x.2011.01.003

›› 2011, Vol. 23 ›› Issue (1): 9-012.doi: 10.3969/j.issn.1004-616x.2011.01.003

MnSOD基因单核苷酸多态性对食管癌局部放疗的影响

程云杰,王雅棣*,刘青,张钧,万欣

河北医科大学第四医院放疗科一病区

收稿日期:2010-04-09 修回日期:2010-10-10 出版日期:2011-01-30 发布日期:2011-01-30
通讯作者: 王雅棣

Influence of MnSOD gene polymorphism on the curative effect of radiotherapy in esophageal squamous cell carcinoma

CHENG Yun-jie,WANG Ya-di*,LIU Qing,ZHANG Jun,WAN Xin

Department of Radiotherapy,The Fourth Hospital of HeBei Medical Univercity

Received:2010-04-09 Revised:2010-10-10 Online:2011-01-30 Published:2011-01-30
Contact: WANG Ya-di

摘要/Abstract

摘要： 探讨锰超氧化物歧化酶(manganese superoxide dismutase，MnSOD)基因单核苷酸多态性与食管癌放疗敏感性的关系。方法：以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析93例食管癌患者外周血白细胞DNA的MnSOD基因第16密码子多态性(Ala16Val rs4880)；通过比较食管癌放疗的局部疗效，分析携带MnSOD基因野生型(T/ T)与突变基因型(T/C、C/C)食管癌患者对放疗的敏感性差异。结果：放疗后局部疗效达完全缓解者(CR)者22例、部分缓解者(PR)者63例，无缓解(NR)者8例，其MnSOD基因第16密码子多态性(T/T、T/C＋C/C)分布频率分别为59.1%、40.9%；77.8%、22.2%；62.5%、37.5%，3者之间差异无统计学意(χ2＝3.223，P＞0.05)。在食管癌病变长度≤5cm的患者中CR与PR、NR 之间MnSOD(T/T、T/C＋C/C)基因型分布频率的差异无统计学意义(χ2＝2.658，P＞0.05)；而病变长度＞5cm的患者中携带C等位基因患者的疗效优于携带T/T基因型患者。MnSOD(T/T、T/C＋C/C)基因型患者的中位生存时间和1年生存率分别为17个月和68%；22个月和73%，但T/T与T/C＋C/C基因型之间的差异无统计学意义(P＞0.05)。结论：病变长度＞5 cm患者中，携带T/C或C/C基因型患者放疗对肿瘤的治疗效果优于携带T/T基因型患者。

关键词: 食管癌, 锰超氧化物歧化酶, 单核苷酸多态性, 放疗敏感性, 局部疗效

Abstract: To investigate the association of single nucleotide polymorphisms of (manganese superoxide dismutase, MnSOD) gene with radiosensitivity of esophageal squamous cell carcinoma. METHODS： The MnSOD Ala16Val was genotyped by polymerase-chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis in 93 esophageal squamous cell carcinoma patients. All patients received 3D-CRT or the conventional radiotherapy. RESULTS: The frequencies of T/T and C/T+C/C allelotype among three grades of curative effect were 59.1%, 40.9%; 77.8%, 22.2%; 62.5%, 37.5% respectively. There was no statistical difference in allelotype distribution between three grades. When the length of esophagus cancer was 5 cm or less than there was no statistical difference in allelotype distribution between three grades of curative effect. But when the length was more than 5 cm a significant difference was observed in the MnSOD allelotype distribution among different length (χ2=2.658, P＜0.05). The curative effect of radiotherapy in patients with C/T+C/C allelotype was better than patients with allelotype T/T when the length was more than 5 cm. There was no difference of MST and 1-year survival rates in patients with MnSOD-9 T/T genotype and MnSOD-9 T/C＋C/C genotype(17 months, 68%, 35.82% vs 22 months, 73%,34.62% P > 0.05). CONCLUSION： The MnSOD Ala16Val appears to be associated with an improved radiosensitivity in patients when the length of esophagus lesion was more than 5 cm.

Key words: esophageal squamous cell carcinoma, manganese superoxide dismutase, single nucleotide polymorphism, radiosensitivity, curative effect

程云杰,王雅棣*,刘青,张钧,万欣. MnSOD基因单核苷酸多态性对食管癌局部放疗的影响[J]. , 2011, 23(1): 9-012.

CHENG Yun-jie,WANG Ya-di*,LIU Qing,ZHANG Jun,WAN Xin. Influence of MnSOD gene polymorphism on the curative effect of radiotherapy in esophageal squamous cell carcinoma[J]. , 2011, 23(1): 9-012.

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MnSOD基因单核苷酸多态性对食管癌局部放疗的影响

Influence of MnSOD gene polymorphism on the curative effect of radiotherapy in esophageal squamous cell carcinoma

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